The subject says it all.
My own "Linux audio sucks" hobbyhorse:
No way to recall a complex configuration of apps and plugins with
all settings intact. If I use a complicated setup with multiple synths
and plugins I have no way to recall these applications to their previous
settings. LASH/LADCCA was supposed to address this situation but I don't
know where that project stands at this point.
And your favorite is... ?